Purified Anti-Human CD32 Antibody[IV-3], Functional Grade (E-AB-F10750)
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For research use only.
| Alternate Names | FCG, CDw, Fcgr, IGFR, FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2, CDw32, Fc-gamma-RIIb, FcRII-b, Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, Fc-gamma RII-b, CD32 antigen, Fc fragment of IgG, Fc gamma receptor IIB, Fc gamma RII, Fc gamma RIIB, FCG2B, Fc-gamma RII, FCRII, FcγRⅡ, IgG Fc receptor II beta, low affinity II, low affinity IIb, Low affinity immunoglobulin gamma Fc region receptor II, Ly-17, Lym 1, Lymphocyte antigen 17, receptor, receptor (CD32), receptor for, receptor for (CD32) |
| Clone | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: Human peripheral blood granulocyte |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells);Block Reported in the literaturee |
| Background | CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcγRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform). None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Immunogen | Recombinant Human CD32 protein |
| Abbre | CD32 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG2b, κ |
| Isotype Control | Purified Mouse IgG2b, κ Isotype Control[MPC-11], Functional Grade |
| Applications |
FCM;Block
|
| Research Areas | Immunology;Stem Cells |
| Concentration |
≥ 1 mg/mL
|
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Application References | Sanae Ben Mkaddem, et al. J Clin Invest. 2014 Sep;124(9):3945-59. |
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